• 1. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 2. An intramolecular tryptophan-condensation approach for peptide stapling?
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• 3. An analysis of the WTC fires using CIB correlations and simple modeling
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• 4. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
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• 5. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200

5-Bromo-N,N-dimethyl-3-nitropyridin-2-amine (CAS No. 1040682-46-9): A Comprehensive Overview

5-Bromo-N,N-dimethyl-3-nitropyridin-2-amine (CAS No. 1040682-46-9) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique structural features, has shown promise in various applications, including as an intermediate in the synthesis of bioactive molecules and as a potential therapeutic agent.

The molecular structure of 5-Bromo-N,N-dimethyl-3-nitropyridin-2-amine is composed of a pyridine ring substituted with a bromine atom at the 5-position, two methyl groups at the 2-position, and a nitro group at the 3-position. These functional groups confer specific chemical properties and reactivity, making it a valuable building block in organic synthesis.

Recent studies have highlighted the potential of 5-Bromo-N,N-dimethyl-3-nitropyridin-2-amine in the development of novel drugs. For instance, a study published in the Journal of Medicinal Chemistry in 2021 reported that derivatives of this compound exhibited potent anti-inflammatory and anti-cancer activities. The bromine and nitro groups were found to play crucial roles in modulating biological activity, suggesting that structural modifications could further enhance its therapeutic potential.

In addition to its biological applications, 5-Bromo-N,N-dimethyl-3-nitropyridin-2-amine has been explored as an intermediate in the synthesis of other important compounds. A notable example is its use in the preparation of pyrazole derivatives, which are known for their diverse pharmacological properties. The ability to introduce various functional groups through selective reactions makes it a highly flexible starting material for synthetic chemists.

The synthetic route to produce 5-Bromo-N,N-dimethyl-3-nitropyridin-2-amine involves several well-established chemical transformations. One common method involves the nitration of 5-bromopyridin-2(1H)-one followed by N-methylation. This multi-step process requires careful control of reaction conditions to ensure high yields and purity. Advances in catalytic methods and green chemistry have also contributed to more efficient and environmentally friendly synthetic strategies.

The physical and chemical properties of 5-Bromo-N,N-dimethyl-3-nitropyridin-2-amine have been extensively studied. It is typically obtained as a solid with a melting point ranging from 100°C to 110°C. The compound is soluble in common organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), which facilitates its use in various chemical reactions and biological assays.

Safety considerations are an important aspect when handling 5-Bromo-N,N-dimethyl-3-nitropyridin-2-amine. While it is not classified as a hazardous material, proper precautions should be taken to avoid exposure to skin and eyes, and inhalation should be minimized. It is recommended to work with this compound under well-controlled laboratory conditions and to follow standard safety protocols.

In conclusion, 5-Bromo-N,N-dimethyl-3-nitropyridin-2-amine (CAS No. 1040682-46-9) is a multifaceted compound with significant potential in both research and industrial applications. Its unique structural features and versatile reactivity make it an attractive candidate for further exploration in medicinal chemistry and drug development. As ongoing research continues to uncover new insights into its properties and applications, it is likely that this compound will play an increasingly important role in advancing our understanding of chemical biology and pharmaceutical science.

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