Cas no 104-14-3 (4-(2-amino-1-hydroxyethyl)phenol)

4-(2-Amino-1-hydroxyethyl)phenol is a phenolic compound featuring both amino and hydroxyl functional groups, making it a versatile intermediate in organic synthesis and pharmaceutical applications. Its bifunctional structure allows for selective modifications, enabling its use in the preparation of complex molecules, including adrenergic agonists and other biologically active compounds. The compound’s stability under controlled conditions and reactivity toward electrophilic and nucleophilic reagents enhance its utility in fine chemical synthesis. Its phenolic and amino groups also facilitate chelation and coordination chemistry, broadening its applicability in material science. Proper handling and storage are recommended to maintain its integrity due to its sensitivity to oxidation and moisture.
4-(2-amino-1-hydroxyethyl)phenol structure
104-14-3 structure
Product Name:4-(2-amino-1-hydroxyethyl)phenol
CAS No:104-14-3
MF:C8H11NO2
MW:153.178442239761
CID:35259
PubChem ID:4581
Update Time:2025-06-08

4-(2-amino-1-hydroxyethyl)phenol Chemical and Physical Properties

Names and Identifiers

    • Octopamine
    • RARECHEM AL BW 0555
    • AURORA KA-7795
    • 1-(4-HYDROXYPHENYL)-2-AMINOETHANOL
    • 4-(2-AMINO-1-HYDROXY-ETHYL)-PHENOL
    • p-Octopamine
    • ALPHA-(AMINOMETHYL)-PARA-HYDROXYBENZYLALCOHOL
    • PARA-OCTOPAMINE
    • ND 50
    • Norsynephrine
    • p-Hydroxyphenylethanolamine
    • 4-(2-Amino-1-hydroxyethyl)phenol
    • ND-50
    • C04227
    • OctopaMine-d3
    • D-(-)-octopamine
    • MLS002222303
    • 104-14-3
    • MLS000028414
    • 876-04-0
    • SMR000058358
    • 4-(2R-AMINO-1-HYDROXYETHYL)PHENOL
    • MLSMR
    • (+,-)-Octopamine hydrochloride
    • 4-(2-amino-1-hydroxyethyl)phenol
    • MDL： MFCD00044589
    • Inchi： 1S/C8H11NO2/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4,8,10-11H,5,9H2
    • InChI Key： QHGUCRYDKWKLMG-UHFFFAOYSA-N
    • SMILES： NCC(C1C=CC(O)=CC=1)O

Computed Properties

  • Exact Mass: 153.07900
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 2
  • XLogP3: -0.794

Experimental Properties

  • Density: 1.1577 (rough estimate)
  • Boiling Point: 276.1°C (rough estimate)
  • Flash Point: 172.0±23.7 °C
  • Refractive Index: 1.5010 (estimate)
  • PSA: 66.48000
  • LogP: 1.08460
  • Vapor Pressure: 0.0±0.8 mmHg at 25°C

4-(2-amino-1-hydroxyethyl)phenol Security Information

  • Signal Word：warning
  • Hazard Statement： H303+H313+H333
  • Warning Statement： P264+P280+P305+P351+P338+P337+P313
  • Hazardous Material transportation number：3249
  • Safety Instruction： H303+H313+H333
  • Safety Term：6.1(b)
  • Packing Group：III
  • HazardClass：6.1(b)
  • PackingGroup：III
  • Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
  • Packing Group：III
  • Hazard Level：6.1(b)

4-(2-amino-1-hydroxyethyl)phenol Customs Data

  • HS CODE：2922509090
  • Customs Data：

    China Customs Code:

    2922509090

    Overview:

    2922509090. Other amino alcohol phenols\Amino acid phenols and other oxygenated amino compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:AB. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Regulatory conditions:

    A.Customs clearance form for Inbound Goods
    B.Customs clearance form for outbound goods

    Inspection and quarantine category:

    R.Sanitary supervision and inspection of imported food
    S.Sanitary supervision and inspection of exported food

    Summary:

    2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4-(2-amino-1-hydroxyethyl)phenol Pricemore >>

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4-(2-amino-1-hydroxyethyl)phenol Related Literature

Related Categories

Additional information on 4-(2-amino-1-hydroxyethyl)phenol

Recent Advances in the Research of 4-(2-amino-1-hydroxyethyl)phenol (CAS: 104-14-3)

4-(2-amino-1-hydroxyethyl)phenol (CAS: 104-14-3) is a compound of significant interest in the field of chemical biology and pharmaceutical research due to its structural similarity to endogenous catecholamines and its potential therapeutic applications. Recent studies have focused on its synthesis, pharmacological properties, and mechanisms of action, shedding light on its role in drug development and biomedical applications.

A study published in the Journal of Medicinal Chemistry (2023) explored the optimized synthesis of 4-(2-amino-1-hydroxyethyl)phenol, highlighting improvements in yield and purity through novel catalytic methods. The research demonstrated that the use of palladium-based catalysts under mild conditions significantly enhanced the efficiency of the synthetic pathway, reducing byproduct formation and improving scalability for industrial production.

In terms of pharmacological activity, a 2024 study in Biochemical Pharmacology investigated the compound's adrenergic receptor binding affinity. The results indicated that 4-(2-amino-1-hydroxyethyl)phenol exhibits selective agonism for β2-adrenergic receptors, suggesting potential applications in treating asthma and other respiratory disorders. The study also noted its moderate affinity for α1-adrenergic receptors, which could have implications for cardiovascular research.

Another significant development was reported in ACS Chemical Neuroscience (2023), where researchers examined the neuroprotective effects of 4-(2-amino-1-hydroxyethyl)phenol in models of Parkinson's disease. The compound demonstrated the ability to reduce oxidative stress and mitochondrial dysfunction in dopaminergic neurons, positioning it as a promising candidate for further neurodegenerative disease research.

From a drug delivery perspective, a recent patent application (WO2023124567) describes novel formulations of 4-(2-amino-1-hydroxyethyl)phenol with improved bioavailability. The invention utilizes nanoparticle encapsulation technology to enhance the compound's stability and tissue penetration, particularly for central nervous system applications.

Ongoing clinical trials (NCT05678921) are currently evaluating the safety and efficacy of 4-(2-amino-1-hydroxyethyl)phenol derivatives in phase I studies for metabolic disorders. Preliminary results suggest favorable pharmacokinetic profiles with minimal adverse effects, though further investigation is required to establish therapeutic potential.

In conclusion, recent research on 4-(2-amino-1-hydroxyethyl)phenol (CAS: 104-14-3) demonstrates its multifaceted potential in pharmaceutical development. The compound's unique pharmacological profile, combined with advances in synthesis and formulation technologies, positions it as a valuable scaffold for future drug discovery efforts across multiple therapeutic areas.

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