• 1. Frontier orbital engineering of photo-hydrogen-evolving molecular devices: a clear relationship between the H2-evolving activity and the energy level of the LUMO
  Shigeyuki Masaoka,Yuichiro Mukawa,Ken Sakai Dalton Trans. 2010 39 5868
• 2. Dinuclear manganese complexes for water oxidation: evaluation of electronic effects and catalytic activity
  Wael A. A. Arafa,Markus D. K?rk?s,Bao-Lin Lee,Torbj?rn ?kermark,Rong-Zhen Liao,Hans-Martin Berends,Johannes Messinger,Per E. M. Siegbahn,Bj?rn ?kermark Phys. Chem. Chem. Phys. 2014 16 11950
• 3. Synthesis, characterisation and photophysical studies of leucotriarylmethanes-containing ligands and their rhenium(i) tricarbonyl diimine complexes
  Chi-Chiu Ko,Chi-On Ng,Hua Feng,Wing-Kin Chu Dalton Trans. 2010 39 6475
• 4. A ruthenium–oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy
  Luke K. McKenzie,Marie Flamme,Patrick S. Felder,Johannes Karges,Frederic Bonhomme,Albert Gandioso,Christian Malosse,Gilles Gasser,Marcel Hollenstein RSC Chem. Biol. 2022 3 85
• 5. Synthesis and photophysical properties of kinetically stable complexes containing a lanthanide ion and a transition metal antenna group
  William S. Perry,Simon J. A. Pope,Clémence Allain,Benjamin J. Coe,Alan M. Kenwright,Stephen Faulkner Dalton Trans. 2010 39 10974

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Bipyridines and oligopyridines
• Solvents and Organic Chemicals Organic Compounds

Introduction to 4'-Methyl-2,2'-bipyridine-4-carboxylic Acid (CAS No: 103946-54-9)

The compound 4'-Methyl-2,2'-bipyridine-4-carboxylic acid, identified by the CAS number 103946-54-9, is a significant molecule in the field of organic chemistry and materials science. This compound belongs to the class of bipyridine derivatives, which have gained considerable attention due to their versatile applications in various scientific domains. The structure of this compound consists of two pyridine rings connected by a single bond at the 2-position, with a methyl group attached to the 4' position of one ring and a carboxylic acid group at the 4-position of the other ring.

The synthesis of 4'-Methyl-2,2'-bipyridine-4-carboxylic acid involves a series of carefully designed organic reactions. Recent advancements in synthetic methodologies have enabled researchers to optimize the synthesis process, ensuring higher yields and better purity. The key steps typically include nucleophilic aromatic substitution, coupling reactions, and functional group transformations. These methods have been extensively studied and reported in recent scientific literature, highlighting the importance of this compound in both academic and industrial settings.

One of the most notable applications of 4'-Methyl-2,2'-bipyridine derivatives is in the field of coordination chemistry. The bipyridine moiety is known for its ability to act as a ligand in metal complexes, forming stable coordination bonds with transition metals such as copper, iron, and cobalt. The presence of the carboxylic acid group in this compound further enhances its versatility by allowing additional functionalization and compatibility with various metal ions.

In recent years, there has been a growing interest in exploring the potential of carboxylic acid-containing bipyridine derivatives in drug discovery and development. The unique combination of aromaticity and acidic functionality makes this compound an ideal candidate for designing bioactive molecules with specific pharmacological properties. Studies have shown that such compounds can exhibit anti-inflammatory, antioxidant, and even anticancer activities when appropriately functionalized.

The application of 4'-Methyl-2,2'-bipyridine-4-carboxylic acid extends beyond traditional chemistry into materials science as well. Researchers have investigated its use in constructing self-assembled monolayers (SAMs) and supramolecular assemblies. These structures are crucial for developing advanced materials with tailored properties for applications in electronics, sensors, and catalysis.

A recent breakthrough involving this compound involves its use as a building block for constructing metal-organic frameworks (MOFs). MOFs are highly porous materials with potential applications in gas storage, catalysis, and drug delivery systems. The incorporation of bipyridine derivatives into MOFs has been shown to significantly enhance their stability and selectivity under various operating conditions.

In addition to its role in materials science, carboxylic acid-containing bipyridines are also being explored for their potential in catalytic processes. For instance, they can serve as ligands or catalysts themselves in organic transformations such as oxidation reactions or asymmetric synthesis. Their ability to coordinate with metal catalysts makes them valuable tools for improving reaction efficiency and selectivity.

The development of green chemistry practices has further highlighted the importance of compounds like 4'-Methyl-2,2'-bipyridine. Researchers are increasingly focusing on environmentally friendly methods for synthesizing these compounds while maintaining high yields and product quality. This shift towards sustainable chemistry aligns with global efforts to reduce environmental impact while advancing scientific innovation.

In conclusion, CAS No: 103946-54-9, or 4'-Methyl-2,2'-bipyridine-4-carboxylic acid, stands out as a versatile molecule with wide-ranging applications across multiple disciplines. Its unique chemical structure allows it to serve as a building block for advanced materials and bioactive molecules while contributing to cutting-edge research in coordination chemistry and catalysis.

• 486-73-7(Isoquinoline-1-carboxylic acid)
• 119-91-5(2,2'-Biquinoline)
• 1226205-64-6(2-(4-Methylphenyl)isonicotinic Acid)
• 55240-51-2(2-Phenylisonicotinic acid)
• 58792-53-3(Methyl [2,2'-bipyridine]-4-carboxylate)
• 93-10-7(Quinoline-2-carboxylic acid)
• 117-57-7(3-Hydroxy-2-methyl-4-quinolinecarboxylic acid)
• 100004-94-2(2-(m-Tolyl)isonicotinic acid)
• 59-67-6(Niacin)
• 1748-89-6(2,2'-Bipyridine-4-carboxylic acid)