Cas no 103913-29-7 (N-4-(Morpholin-4-yl)phenylacetamide)

N-4-(Morpholin-4-yl)phenylacetamide is a synthetic organic compound featuring a morpholine-substituted phenylacetamide structure. Its key advantages include its role as a versatile intermediate in pharmaceutical and agrochemical synthesis, particularly in the development of bioactive molecules. The morpholine moiety enhances solubility and bioavailability, while the acetamide group provides a reactive site for further functionalization. This compound exhibits stability under standard storage conditions and is compatible with a range of chemical transformations, making it valuable for medicinal chemistry research. Its well-defined structure and purity ensure reproducibility in synthetic applications, supporting its use in drug discovery and material science.
N-4-(Morpholin-4-yl)phenylacetamide structure
103913-29-7 structure
Product Name:N-4-(Morpholin-4-yl)phenylacetamide
CAS No:103913-29-7
MF:C12H16N2O2
MW:220.267642974854
MDL:MFCD00172684
CID:1139728
PubChem ID:700557
Update Time:2025-05-21

N-4-(Morpholin-4-yl)phenylacetamide Chemical and Physical Properties

Names and Identifiers

    • Acetamide, N-[4-(4-morpholinyl)phenyl]-
    • N-(4-morpholin-4-ylphenyl)acetamide
    • N-[4-(morpholin-4-yl)phenyl]acetamide
    • AB00076840-01
    • SR-01000408775-1
    • FWCIAVMWCOEWGF-UHFFFAOYSA-N
    • Cambridge id 5255410
    • N-(4-Morpholin-4-yl-phenyl)-acetamide
    • AKOS000431871
    • 4'-MORPHOLINOACETANILIDE
    • SDCCGMLS-0064812.P001
    • MFCD00172684
    • CBMicro_029984
    • 103913-29-7
    • N-(4-morpholinophenyl)acetamide
    • SCHEMBL429085
    • STK394999
    • 10G-318S
    • SR-01000408775
    • CS-0207395
    • BIM-0029999.P001
    • DTXSID60351449
    • N-4-(Morpholin-4-yl)phenylacetamide
    • MDL: MFCD00172684
    • Inchi: 1S/C12H16N2O2/c1-10(15)13-11-2-4-12(5-3-11)14-6-8-16-9-7-14/h2-5H,6-9H2,1H3,(H,13,15)
    • InChI Key: FWCIAVMWCOEWGF-UHFFFAOYSA-N
    • SMILES: O1CCN(C2C=CC(=CC=2)NC(C)=O)CC1

Computed Properties

  • Exact Mass: 220.12128
  • Monoisotopic Mass: 220.121177757g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 2
  • Complexity: 231
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.8
  • Topological Polar Surface Area: 41.6?2

Experimental Properties

  • PSA: 41.57

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Additional information on N-4-(Morpholin-4-yl)phenylacetamide

Compound CAS No. 103913-29-7: N-4-(Morpholin-4-yl)phenylacetamide

The compound N-4-(Morpholin-4-yl)phenylacetamide (CAS No. 103913-29-7) is a versatile organic molecule with significant applications in various fields, including pharmaceuticals, agrochemicals, and materials science. This compound is characterized by its unique structure, which combines a morpholine ring and a phenylacetamide group, making it a valuable building block for further chemical modifications and functionalization.

Recent studies have highlighted the potential of N-4-(Morpholin-4-yl)phenylacetamide in drug discovery, particularly in the development of bioactive compounds with anti-inflammatory and neuroprotective properties. Researchers have explored its ability to modulate key cellular pathways, such as the NF-kB signaling cascade, which is implicated in chronic inflammatory diseases. The compound's morpholine moiety has been shown to enhance its bioavailability and stability, making it an attractive candidate for preclinical studies.

In addition to its pharmacological applications, N-4-(Morpholin-4-yl)phenylacetamide has been utilized in the synthesis of advanced materials, such as stimuli-responsive polymers and self-healing coatings. Its phenylacetamide group provides excellent compatibility with various polymer matrices, enabling the creation of materials with tailored mechanical and thermal properties. Recent advancements in green chemistry have also led to the development of more sustainable synthesis routes for this compound, reducing its environmental footprint.

The synthesis of N-4-(Morpholin-4-yl)phenylacetamide typically involves a multi-step process, including nucleophilic substitution and amide bond formation. The reaction conditions are carefully optimized to ensure high yield and purity. For instance, recent research has demonstrated the use of microwave-assisted synthesis to accelerate the reaction process while maintaining product quality. This approach not only enhances efficiency but also aligns with the growing demand for energy-efficient chemical manufacturing.

From a structural perspective, N-4-(Morpholin-4-yl)phenylacetamide exhibits a planar aromatic system due to the conjugation between the phenyl ring and the carbonyl group. This planarity contributes to its electronic properties, making it suitable for applications in optoelectronics and organic electronics. For example, studies have shown that this compound can be incorporated into organic field-effect transistors (OFETs), where it acts as a semiconducting layer with improved charge transport characteristics.

The toxicity profile of N-4-(Morpholin-4-yl)phenylacetamide has also been extensively studied to ensure its safe use in various applications. Acute toxicity tests indicate that it has a low toxicity profile when administered at recommended doses. However, chronic exposure studies are still underway to fully understand its long-term effects on human health and the environment.

In conclusion, N-4-(Morpholin-4-yl)phenylacetamide (CAS No. 103913-29-) is a multifaceted compound with promising potential across diverse industries. Its unique structure, combined with recent advancements in synthesis and application techniques, positions it as a key player in future innovations. As research continues to uncover new functionalities and optimize its properties, this compound is expected to play an increasingly important role in both academic and industrial settings.

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