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  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 3. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
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• 4. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
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• 5. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Aldehydes

2-Fluoro-5-hydroxybenzaldehyde (CAS No. 103438-84-2): A Comprehensive Overview

2-Fluoro-5-hydroxybenzaldehyde (CAS No. 103438-84-2) is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, medicinal chemistry, and materials science. This compound, also known as 2-fluoro-5-hydroxybenzaldehyde, is characterized by its unique molecular structure, which includes a fluorine atom and a hydroxyl group attached to a benzaldehyde framework. The combination of these functional groups imparts distinct chemical properties and reactivity, making it a valuable intermediate in various synthetic pathways.

The molecular formula of 2-Fluoro-5-hydroxybenzaldehyde is C₇H₅FO₂, and its molecular weight is approximately 146.11 g/mol. The compound exists as a white to off-white solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). Its physical and chemical properties have been extensively studied, providing a solid foundation for its application in diverse scientific and industrial contexts.

In the realm of organic synthesis, 2-Fluoro-5-hydroxybenzaldehyde serves as a key building block for the preparation of complex molecules. The presence of the fluorine atom introduces unique electronic effects that can influence the reactivity and stability of the resulting compounds. For instance, recent studies have demonstrated the utility of this compound in the synthesis of fluorinated aromatic derivatives, which are important in the development of pharmaceuticals and agrochemicals. The hydroxyl group, on the other hand, provides a reactive site for further functionalization through reactions such as esterification, etherification, and acylation.

In medicinal chemistry, 2-Fluoro-5-hydroxybenzaldehyde has shown promise as a precursor for the synthesis of bioactive molecules. Fluorinated compounds are known for their enhanced metabolic stability and improved pharmacokinetic properties, making them attractive candidates for drug development. Recent research has explored the use of this compound in the synthesis of potential anticancer agents and antiviral drugs. For example, a study published in the Journal of Medicinal Chemistry reported the synthesis of a series of 2-fluoro-5-hydroxybenzaldehyde derivatives with potent antiproliferative activity against various cancer cell lines.

The versatility of 2-Fluoro-5-hydroxybenzaldehyde extends beyond medicinal applications to materials science. Fluorinated aromatic compounds are often used in the development of advanced materials with unique properties such as high thermal stability, low surface energy, and enhanced mechanical strength. In this context, 2-Fluoro-5-hydroxybenzaldehyde can serve as a precursor for the synthesis of polymers and copolymers with tailored functionalities. Recent advancements in polymer science have led to the creation of fluorinated polymers with applications in coatings, adhesives, and electronic devices.

The environmental impact of chemical compounds is an important consideration in their development and use. Studies on the biodegradability and toxicity of 2-Fluoro-5-hydroxybenzaldehyde have shown that it exhibits low environmental persistence and minimal toxicity at typical usage levels. This makes it a safer alternative to other aromatic aldehydes that may pose environmental risks. However, proper handling and disposal practices should always be followed to ensure environmental safety.

In conclusion, 2-Fluoro-5-hydroxybenzaldehyde (CAS No. 103438-84-2) is a multifaceted compound with significant potential in various scientific and industrial applications. Its unique combination of functional groups provides a platform for innovative synthetic strategies and the development of novel materials with enhanced properties. As research continues to uncover new possibilities for this compound, its importance in the fields of organic synthesis, medicinal chemistry, and materials science is likely to grow.

• 71144-36-0(3,4-Dihydroxy-6-fluoro-benzaldehyde)
• 105728-90-3(2-Fluoro-5-methoxybenzaldehyde)
• 120951-87-3(Benzaldehyde,2-fluoro-3,5-dihydroxy-)
• 38226-10-7(2-Fluoro-6-hydroxybenzaldehyde)
• 192927-69-8(2,4-Difluoro-3-hydroxybenzaldehyde)
• 920525-52-6(Benzaldehyde, 2-fluoro-6-hydroxy-3-methyl-)
• 348-27-6(2-Fluoro-4-hydroxybenzaldehyde)
• 532967-21-8(2,6-Difluoro-4-hydroxybenzaldehyde)
• 152434-88-3(2,6-Difluoro-3-hydroxybenzaldehyde)
• 61338-95-2(Benzaldehyde, 2-fluoro-3,4-dihydroxy-)