Production Method 1

1032273-54-3

1032273-66-7

94209-24-2

17355-75-8

1032273-33-8

Reaction Conditions

1.1 Catalysts: Hydrochloric acid Solvents: Dimethylformamide ,  Water ;  2 - 5 h, rt; rt → reflux; 3 h, reflux

Reference

Synthesis of bromodifluoromethyl substituted pyrazoles and isoxazoles

Yang, Xueyan; Shui, Shengxia; Chen, Xi; He, Haiou; Wu, Fanhong, Journal of Fluorine Chemistry, 2010, 131(3), 426-432

5-(Bromodifluoromethyl)-1,3-diphenyl-1H-pyrazole Raw materials

• 4-bromo-4,4-difluoro-1-phenylbutane-1,3-dione

5-(Bromodifluoromethyl)-1,3-diphenyl-1H-pyrazole Preparation Products

• ethyl 1,3-diphenyl-1H-pyrazole-5-carboxylate (94209-24-2)
• 1H-Pyrazole-3-carboxylic acid, 1,5-diphenyl-, ethyl ester (17355-75-8)
• 1H-Pyrazole, 3-(bromodifluoromethyl)-1,5-diphenyl- (1032273-33-8)
• 5-(Bromodifluoromethyl)-1,3-diphenyl-1H-pyrazole (1032273-66-7)

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