Cas no 10215-77-7 (Corticosterone 21-Hemisuccinate)

Corticosterone 21-Hemisuccinate is a synthetic corticosteroid derivative, commonly used as an intermediate in the synthesis of more complex steroid compounds. Its key advantage lies in the hemisuccinate ester group at the 21-position, which enhances solubility in aqueous and polar solvents, facilitating further chemical modifications or formulation. This modification also improves bioavailability in certain applications. The compound is valuable in pharmaceutical research, particularly in the development of glucocorticoid receptor studies and anti-inflammatory agents. Its well-defined structure and consistent purity make it a reliable choice for laboratory use. Proper handling and storage are essential to maintain stability and prevent degradation.
Corticosterone 21-Hemisuccinate structure
10215-77-7 structure
Product Name:Corticosterone 21-Hemisuccinate
CAS No:10215-77-7
MF:C25H34O7
MW:446.533268451691
CID:159596
PubChem ID:159273
Update Time:2025-06-09

Corticosterone 21-Hemisuccinate Chemical and Physical Properties

Names and Identifiers

    • Pregn-4-ene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11-hydroxy-, (11b)-
    • corticosterone-21-hemisuccinate
    • 4-{[(11beta)-11-hydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoic acid
    • Corticosterone 21-hemisuccinate
    • Corticosterone hemisuccinate
    • Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11-hydroxy-, (11beta)-
    • 10215-77-7
    • 4-[(11-Hydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoic acid
    • 4-[2-[(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
    • DTXSID40907180
    • Q27280897
    • UNII-IU50V885SP
    • PREGN-4-ENE-3,20-DIONE, 21-(3-CARBOXY-1-OXOPROPOXY)-11-HYDROXY-, (11.BETA.)-
    • IU50V885SP
    • Corticosterone 21-Hemisuccinate
    • Inchi： 1S/C25H34O7/c1-24-10-9-15(26)11-14(24)3-4-16-17-5-6-18(25(17,2)12-19(27)23(16)24)20(28)13-32-22(31)8-7-21(29)30/h11,16-19,23,27H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18+,19-,23+,24-,25-/m0/s1
    • InChI Key： KEECMXYFGNWLEA-BIGDRKAKSA-N
    • SMILES： O[C@H]1C[C@]2(C)[C@@H](C(COC(CCC(=O)O)=O)=O)CC[C@H]2[C@@H]2CCC3=CC(CC[C@]3(C)[C@H]21)=O

Computed Properties

  • Exact Mass: 446.230453g/mol
  • Monoisotopic Mass: 446.230453g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 7
  • Heavy Atom Count: 32
  • Rotatable Bond Count: 7
  • Complexity: 860
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 7
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Molecular Weight: 446.5g/mol
  • XLogP3: 1.9
  • Topological Polar Surface Area: 118?2

Experimental Properties

  • Density: 1.28
  • Boiling Point: 651.3°Cat760mmHg
  • Flash Point: 219.3°C
  • Refractive Index: 1.57

Corticosterone 21-Hemisuccinate Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
C696380-100mg
Corticosterone 21-Hemisuccinate
 10215-77-7
100mg
 $ 167.00 2023-04-17
TRC
C696380-250mg
Corticosterone 21-Hemisuccinate
 10215-77-7
250mg
 $ 385.00 2023-04-17
TRC
C696380-1g
Corticosterone 21-Hemisuccinate
 10215-77-7
1g
 $ 1090.00 2022-06-06
TRC
C696380-1000mg
Corticosterone 21-Hemisuccinate
 10215-77-7
1g
 $ 1315.00 2023-04-17
TRC
C696380-750mg
Corticosterone 21-Hemisuccinate
 10215-77-7
750mg
 $ 800.00 2023-09-08

Corticosterone 21-Hemisuccinate Related Literature

Related Categories

Additional information on Corticosterone 21-Hemisuccinate

Corticosterone 21-Hemisuccinate (CAS No. 10215-77-7): A Comprehensive Overview in Modern Chemical Biology

Corticosterone 21-Hemisuccinate, identified by the chemical formula CAS No. 10215-77-7, is a significant compound in the field of chemical biology and pharmaceutical research. This derivative of corticosterone, a naturally occurring steroid hormone, has garnered considerable attention due to its unique biochemical properties and potential therapeutic applications. The hemisuccinate esterification at the 21-position introduces specific functionalities that enhance its reactivity and utility in synthetic chemistry and biological assays.

The structural modification of corticosterone to form its 21-hemisuccinate derivative imparts distinct pharmacological characteristics, making it a valuable intermediate in the synthesis of more complex steroid analogs. In recent years, advancements in enzymatic and chemical synthesis methods have improved the yield and purity of this compound, facilitating its use in high-throughput screening programs and structural biology studies.

One of the most compelling aspects of Corticosterone 21-Hemisuccinate is its role as a precursor in the development of novel therapeutic agents. Researchers have leveraged its scaffold to design molecules with enhanced binding affinity and selectivity for steroid receptors. For instance, studies have demonstrated its utility in creating derivatives with potential applications in treating inflammatory disorders and metabolic diseases. The hemisuccinate moiety facilitates further chemical modifications, allowing for the introduction of diverse functional groups that can fine-tune biological activity.

Recent investigations have also highlighted the compound's significance in understanding steroid hormone metabolism. By studying Corticosterone 21-Hemisuccinate, scientists have gained insights into the enzymatic pathways responsible for steroid biosynthesis and degradation. These findings are crucial for developing strategies to modulate hormonal balance in physiological and pathological conditions. Additionally, the compound's stability under various environmental conditions makes it an ideal candidate for industrial-scale synthesis, ensuring consistent quality for research and commercial purposes.

The pharmaceutical industry has been particularly interested in exploring the potential of Corticosterone 21-Hemisuccinate as a lead compound for drug development. Its structural features allow for easy derivatization, enabling the creation of libraries of compounds with tailored pharmacokinetic properties. High-resolution crystallographic studies have provided detailed insights into its interactions with biological targets, aiding in the rational design of next-generation therapeutics. These efforts are complemented by computational modeling techniques, which predict how different modifications will affect the compound's efficacy and safety profiles.

In conclusion, Corticosterone 21-Hemisuccinate (CAS No. 10215-77-7) represents a cornerstone in modern chemical biology research. Its unique structural attributes and versatile reactivity make it indispensable for developing innovative treatments across multiple therapeutic domains. As synthetic methodologies continue to evolve, the potential applications of this compound are expected to expand further, reinforcing its importance in both academic and industrial settings.

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