• 1. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 2. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 3. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
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  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

Professional Introduction to N-Ethyl 4-bromo-3-methylbenzamide (CAS No. 1020252-82-7)

N-Ethyl 4-bromo-3-methylbenzamide, with the chemical formula C₁₀H₁₀BrNO, is a significant compound in the field of pharmaceutical chemistry and medicinal research. This compound is characterized by its unique structural features, which include a benzamide core substituted with a bromine atom at the 4-position and a methyl group at the 3-position, further modified by an ethyl amine moiety. The presence of these functional groups makes it a versatile intermediate in the synthesis of various bioactive molecules.

The CAS number 1020252-82-7 provides a unique identifier for this compound, ensuring precise classification and referencing in scientific literature and databases. This numbering system is crucial for researchers to accurately retrieve and cite information related to N-Ethyl 4-bromo-3-methylbenzamide, facilitating efficient communication and collaboration within the scientific community.

In recent years, N-Ethyl 4-bromo-3-methylbenzamide has garnered attention due to its potential applications in drug discovery and development. The benzamide scaffold is well-known for its pharmacological properties, often serving as a key structural element in therapeutic agents targeting various diseases. The bromine substituent enhances the reactivity of the molecule, making it a valuable building block for further chemical modifications.

One of the most compelling aspects of N-Ethyl 4-bromo-3-methylbenzamide is its role as a precursor in the synthesis of more complex molecules. Researchers have leveraged its structural framework to develop novel compounds with enhanced biological activity. For instance, studies have shown that derivatives of this benzamide can exhibit potent inhibitory effects on certain enzymes and receptors, making them promising candidates for treating conditions such as inflammation and neurodegenerative disorders.

The ethyl amine group in N-Ethyl 4-bromo-3-methylbenzamide contributes to its versatility, allowing for further functionalization through various chemical reactions such as nucleophilic substitution or coupling reactions. This flexibility has enabled scientists to create a diverse array of analogs with tailored properties, optimizing their efficacy and selectivity for specific therapeutic targets.

Recent advancements in computational chemistry have also highlighted the importance of N-Ethyl 4-bromo-3-methylbenzamide in virtual screening campaigns. Molecular modeling techniques have been employed to predict the binding affinity of this compound and its derivatives to biological targets, streamlining the drug discovery process. These computational approaches have accelerated the identification of lead compounds, reducing the time and resources required for experimental validation.

In addition to its pharmaceutical applications, N-Ethyl 4-bromo-3-methylbenzamide has shown promise in materials science research. The unique electronic properties of its aromatic system make it a candidate for developing organic semiconductors and other advanced materials. By incorporating this compound into polymer matrices, researchers aim to enhance the conductivity and stability of these materials, opening up new possibilities for applications in electronics and renewable energy technologies.

The synthesis of N-Ethyl 4-bromo-3-methylbenzamide typically involves multi-step organic reactions starting from commercially available precursors. The bromination step at the 4-position is critical and often requires careful optimization to ensure high yield and purity. Similarly, the introduction of the methyl group at the 3-position must be carefully controlled to avoid unwanted side reactions. Advances in synthetic methodologies have improved the efficiency and scalability of these processes, making it more feasible to produce larger quantities of this compound for research purposes.

Quality control plays a pivotal role in ensuring the consistency and reliability of N-Ethyl 4-bromo-3-methylbenzamide for both academic and industrial applications. Analytical techniques such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and high-performance liquid chromatography (HPLC) are routinely employed to confirm the identity and purity of the compound. These analytical methods provide detailed structural information and quantify impurities, ensuring that researchers receive a product meeting stringent specifications.

The growing interest in N-Ethyl 4-bromo-3-methylbenzamide has led to increased collaboration between academic institutions and pharmaceutical companies. Joint research initiatives aim to explore new synthetic routes, optimize production processes, and discover novel applications for this compound. Such collaborations foster innovation and accelerate progress in drug development by leveraging complementary expertise and resources.

The future prospects for N-Ethyl 4-bromo-3-methylbenzamide are promising, with ongoing research uncovering new possibilities for its use in medicine and materials science. As our understanding of molecular interactions continues to evolve, this compound is likely to play an increasingly important role in developing next-generation therapeutics and advanced materials. The combination of its structural versatility and functional properties makes it a valuable asset in the chemist's toolkit.

• 8002-31-1(2-Bromo-N-ethylbenzamide)
• 1020252-79-2(N-Propyl 4-Bromo-3-methylbenzamide)
• 82082-50-6(N-Benzyl 2-bromobenzamide)
• 80031-02-3(N-Ethyl 2-bromobenzamide)
• 1065073-96-2(4-Bromo-N-butyl-3-methylbenzamide)
• 8002-23-1(2-Bromo-N-ethylbenzamide)
• 41882-25-1(N-Ethyl 4-bromobenzamide)
• 8002-73-1(2-Bromo-N-ethylbenzamide)
• 8008-31-9(2-Bromo-N-ethylbenzamide)
• 1020252-77-0(N-Isopropyl 4-bromo-3-methylbenzamide)