Production Method 1

102-46-5

824-45-3

824-55-5

Reaction Conditions

1.1 Reagents: Carbon tetrachloride Catalysts: Acetonitrile ,  Molybdenum hexacarbonyl ;  1 h, 170 °C

Reference

Synthesis of benzyl chlorides and diarylmethanes via coupled reactions of methylarenes with carbon tetrachloride in the presence of manganese- and molybdenum-containing catalysts

Khusnutdinov, R. I.; et al, Neftekhimiya, 2004, 44(4), 293-300

Production Method 2

102-46-5

41381-35-5

824-45-3

824-55-5

31053-96-0

1746-26-5

Reaction Conditions

1.1 Reagents: Chlorine dioxide Solvents: Water ;  1.75 h, rt
1.2 Reagents: Sodium thiosulfate

Reference

Chlorination and oxidation products formed from 1,2,4-trimethylbenzene in aqueous solution under the action of chlorine dioxide

Khasanova, Z. R.; et al, Russian Journal of Applied Chemistry, 2007, 80(7), 1105-1110

3,4-Dimethylbenzyl chloride Preparation Products

• BENZENE, 2-CHLORO-1,3,4-TRIMETHYL- (41381-35-5)
• 3,4-Dimethylbenzyl chloride (102-46-5)
• 2-(chloromethyl)-1,4-dimethylbenzene (824-45-3)
• 1-(chloromethyl)-2,4-dimethylbenzene (824-55-5)
• 1-Chloro-2,4,5-trimethylbenzene (31053-96-0)
• Benzene, 1-chloro-4-(chloromethyl)-2,5-dimethyl- (1746-26-5)

• 1. 266. The halogenation of phenolic ethers and anilides. Part IX. The influence of fluorine and of alkyl groups
  Brynmor Jones J. Chem. Soc. 1938 1414
• 2. Development of highly sensitive 1,4-dioxane sensor with semiconductor NiO-doped Nd2O3 nanostructures by electrochemical approach
  Mohammed M. Rahman,Abdul Wahid,Abdullah M. Asiri New J. Chem. 2019 43 17395
• 3. Developing novel zinc(ii) and copper(ii) Schiff base complexes: combined experimental and theoretical investigation on their DNA/protein binding efficacy and anticancer activity
  Manik Das,Somali Mukherjee,Biplab Koley,Indranil Choudhuri,Nandan Bhattacharyya,Pritam Roy,Bidhan Chandra Samanta,Manas Barai,Tithi Maity New J. Chem. 2020 44 18347
• 4. Construction of alkyl-substituted pentaphosphido ligands in the coordination sphere of cobalt
  Christoph G. P. Ziegler,Thomas M. Maier,Stefan Pelties,Clemens Taube,Felix Hennersdorf,Andreas W. Ehlers,Jan J. Weigand,Robert Wolf Chem. Sci. 2019 10 1302
• 5. 888. The mechanism of epoxide reactions. Part X. The reactions of (epoxyethyl)benzene with m-chloro-, 3,4-dimethyl-, and o-(hydroxymethyl)-benzylamine
  R. M. Laird,R. E. Parker J. Chem. Soc. 1965 4784

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl halides Benzyl chlorides

3,4-Dimethylbenzyl Chloride (CAS No. 102-46-5): Properties, Applications, and Market Insights

3,4-Dimethylbenzyl chloride (CAS No. 102-46-5) is a versatile organic compound widely used in the chemical industry. This aromatic chloride is a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and specialty chemicals. Its molecular formula is C₉H₁₁Cl, and it is known for its high reactivity due to the presence of a benzyl chloride group.

The compound is characterized by its colorless to pale yellow liquid appearance and a distinct aromatic odor. With a boiling point of approximately 220-222°C and a melting point of -10°C, 3,4-dimethylbenzyl chloride is soluble in most organic solvents but poorly soluble in water. These properties make it an ideal candidate for various chemical reactions, including alkylation and nucleophilic substitution.

One of the most common applications of 3,4-dimethylbenzyl chloride is in the pharmaceutical industry, where it serves as a building block for drug synthesis. Researchers and manufacturers frequently search for "3,4-dimethylbenzyl chloride uses in medicine" due to its role in producing active pharmaceutical ingredients (APIs). Additionally, it is used in the development of agrochemicals, such as herbicides and pesticides, making it a critical component in modern agriculture.

In recent years, the demand for 3,4-dimethylbenzyl chloride has increased due to its applications in material science. For instance, it is used in the synthesis of polymers and resins, which are essential in coatings, adhesives, and electronic materials. Searches like "3,4-dimethylbenzyl chloride in polymer synthesis" reflect the growing interest in this area.

The global market for 3,4-dimethylbenzyl chloride is expected to grow steadily, driven by advancements in pharmaceutical research and sustainable agriculture. Companies are increasingly focusing on green chemistry and eco-friendly synthesis methods, which align with the rising popularity of searches such as "environmentally friendly production of 3,4-dimethylbenzyl chloride."

For laboratories and industrial users, handling 3,4-dimethylbenzyl chloride requires adherence to safety protocols. Proper storage in cool, dry places away from oxidizing agents is essential to maintain its stability. Questions like "how to store 3,4-dimethylbenzyl chloride safely" are common among professionals working with this compound.

In conclusion, 3,4-dimethylbenzyl chloride (CAS No. 102-46-5) is a valuable chemical intermediate with diverse applications across multiple industries. Its role in pharmaceuticals, agrochemicals, and material science underscores its importance in modern chemistry. As research continues to explore new uses, the compound remains a focal point for innovation and industrial growth.

• 25640-76-0(Benzene,bis(chloromethyl)dimethyl- (6CI,7CI,8CI,9CI))
• 2735-05-9(Benzene,2,4-bis(chloromethyl)-1-methyl-)
• 31345-02-5(Benzene, bis(chloromethyl)-1,3-dimethyl-)
• 3022-16-0(Benzene,1,4-bis(chloromethyl)-2,3,5,6-tetramethyl-)
• 54490-78-7(Benzene, 1,3-bis(chloromethyl)-2,4,5,6-tetramethyl-)
• 2206-83-9(Benzene, 1,2,4,5-tetrakis(chloromethyl)-)
• 2362-16-5(1,2-bis(chloromethyl)-4,5-dimethylbenzene)
• 29002-55-9(Benzene,1,2-bis(chloromethyl)-3,4,5,6-tetramethyl-)
• 41380-66-9(Benzene,(chloromethyl)-1,2,4-trimethyl- (9CI))
• 2387-18-0(Benzene,1,4-bis(chloromethyl)-2-methyl-)