• 1. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 2. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 3. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 4. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 5. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466

Recent Advances in the Study of 2-(Carbazol-9-yl)aniline (CAS: 101716-43-2) and Its Applications in Chemical Biology and Medicine

2-(Carbazol-9-yl)aniline (CAS: 101716-43-2) is a carbazole derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound, characterized by its carbazole-aniline hybrid structure, has been investigated for its potential as a building block in organic synthesis, a fluorescent probe, and a pharmacophore in drug discovery. The unique electronic and steric properties of 2-(Carbazol-9-yl)aniline make it a promising candidate for various biomedical applications, including the development of novel therapeutics and diagnostic tools.

Recent studies have focused on elucidating the molecular mechanisms underlying the biological activities of 2-(Carbazol-9-yl)aniline and its derivatives. One notable area of research involves its role as a fluorescent probe for detecting biomolecules and monitoring cellular processes. The carbazole moiety provides strong fluorescence properties, while the aniline group allows for functionalization, enabling the design of targeted probes. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated the use of 2-(Carbazol-9-yl)aniline-based probes for real-time imaging of reactive oxygen species (ROS) in cancer cells, offering insights into oxidative stress pathways.

In addition to its utility as a fluorescent probe, 2-(Carbazol-9-yl)aniline has been explored as a scaffold for drug development. Researchers have synthesized and evaluated a series of derivatives for their anticancer, antimicrobial, and anti-inflammatory activities. A 2022 study in Bioorganic & Medicinal Chemistry Letters reported that certain 2-(Carbazol-9-yl)aniline derivatives exhibited potent inhibitory effects against tyrosine kinases, which are key targets in cancer therapy. These findings highlight the compound's potential as a lead structure for the design of kinase inhibitors.

The synthetic accessibility of 2-(Carbazol-9-yl)aniline has also facilitated its use in materials science, particularly in the development of organic electronic devices. Its conjugated system and electron-donating properties make it suitable for applications in organic light-emitting diodes (OLEDs) and photovoltaic cells. A 2023 review in Advanced Materials summarized recent advancements in carbazole-based materials, emphasizing the role of 2-(Carbazol-9-yl)aniline in enhancing device performance through improved charge transport and stability.

Despite these promising developments, challenges remain in optimizing the pharmacological and physicochemical properties of 2-(Carbazol-9-yl)aniline derivatives. Future research directions may include structure-activity relationship (SAR) studies to identify more potent and selective analogs, as well as investigations into the compound's toxicity and pharmacokinetic profiles. Collaborative efforts between chemists, biologists, and material scientists will be essential to fully unlock the potential of this versatile molecule.

• 1150-62-5(9-Phenylcarbazole)
• 1484-13-5(9-Vinylcarbazole)
• 580-15-4(6-Aminoquinoline)
• 5192-03-0(1H-Indol-5-amine)
• 132-32-1(3-Amino-9-ethylcarbazole)
• 611-34-7(quinolin-5-amine)
• 578-68-7(quinolin-4-amine)
• 580-19-8(7-Aminoquinoline)
• 603-76-9(1-methyl-1H-indole)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)