Cas no 1012085-50-5 (3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine)

3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is a borylated pyridine derivative featuring two pinacol boronate ester groups at the 3- and 5-positions. This compound serves as a versatile intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of complex biaryl structures with high selectivity. The symmetric substitution pattern enhances reactivity while maintaining stability under standard handling conditions. Its rigid pyridine core facilitates coordination in metal-catalyzed transformations, making it valuable in pharmaceutical and materials science applications. The electron-withdrawing nature of the boronate groups further improves compatibility with diverse reaction conditions. This reagent is particularly useful for constructing conjugated systems in organic electronic materials.
3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine structure
1012085-50-5 structure
Product Name:3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine
CAS No:1012085-50-5
MF:C17H27B2NO4
MW:331.02258515358
MDL:MFCD12923191
CID:1033322
PubChem ID:56973239
Update Time:2025-06-25

3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine Chemical and Physical Properties

Names and Identifiers

    • 3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-Pyridine
    • 3,5-Pridine diboronic acid pinacol ester
    • 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
    • AK119511
    • C17H27B2NO4
    • 0353AA
    • FCH2809184
    • ST2410278
    • AX8244927
    • Pyridine-3,5-bis(boronic acid pinacol ester)
    • 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)pyridine
    • 3,5-Bis(4,4,5,5-tetramethyl-[1,3,2]dioxabor
    • FD10065
    • AKOS016010689
    • A897214
    • 3 pound not5-Bis(4 pound not4 pound not5 pound not5-tetramethyl-1 pound not3 pound not2-dioxaborolan-2-yl)pyridine
    • DTXSID10719898
    • DS-2823
    • Pyridine, 3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
    • 1012085-50-5
    • SCHEMBL12373176
    • CS-W006917
    • MFCD12923191
    • 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine
    • MDL： MFCD12923191
    • Inchi： 1S/C17H27B2NO4/c1-14(2)15(3,4)22-18(21-14)12-9-13(11-20-10-12)19-23-16(5,6)17(7,8)24-19/h9-11H,1-8H3
    • InChI Key： PJLRGJDKNWXNRI-UHFFFAOYSA-N
    • SMILES： O1B(C2C=NC=C(B3OC(C)(C)C(C)(C)O3)C=2)OC(C)(C)C1(C)C

Computed Properties

  • Exact Mass: 331.21300
  • Monoisotopic Mass: 331.2126187g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 24
  • Rotatable Bond Count: 2
  • Complexity: 421
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 49.8

Experimental Properties

  • PSA: 49.81000
  • LogP: 1.68000

3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine Security Information

3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine Customs Data

  • HS CODE：2934999090
  • Customs Data：

    China Customs Code:

    2934999090

    Overview:

    2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine Pricemore >>

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3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine Production Method

3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:1012085-50-5)3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine
Order Number:A897214
Stock Status:in Stock
Quantity:250mg/1g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 11:58
Price ($):154.0/414.0

3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine Related Literature

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Additional information on 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine

Comprehensive Overview of 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine (CAS No. 1012085-50-5)

The compound 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine, with the CAS No. 1012085-50-5, is a highly specialized boronic ester derivative that has garnered significant attention in the fields of organic synthesis, pharmaceuticals, and materials science. Its unique structure, featuring two dioxaborolane groups attached to a pyridine ring, makes it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. Researchers and industries are increasingly exploring its applications due to its stability, reactivity, and compatibility with diverse reaction conditions.

One of the key reasons for the growing interest in 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is its role in the development of advanced organic electronic materials. With the rise of flexible electronics and OLED technologies, this compound has emerged as a critical building block for constructing π-conjugated systems. Its ability to facilitate efficient C-C bond formation under mild conditions aligns perfectly with the demand for sustainable and scalable synthetic routes. Moreover, its boron-containing framework contributes to the tuning of electronic properties, making it invaluable for designing high-performance optoelectronic devices.

In the pharmaceutical sector, CAS No. 1012085-50-5 is recognized for its potential in drug discovery and medicinal chemistry. The pyridine core, combined with the dioxaborolane moieties, offers a platform for creating novel biologically active molecules. Recent studies highlight its utility in the synthesis of kinase inhibitors and anticancer agents, addressing pressing medical challenges. The compound’s stability in aqueous and aerobic environments further enhances its appeal for high-throughput screening and combinatorial chemistry applications.

From an environmental perspective, the use of 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine aligns with the principles of green chemistry. Its participation in atom-economical reactions minimizes waste generation, a critical factor in sustainable industrial processes. Additionally, the compound’s compatibility with Pd-catalyzed reactions reduces the need for hazardous reagents, addressing concerns about chemical safety and regulatory compliance. These attributes make it a preferred choice for researchers aiming to balance efficiency with environmental responsibility.

The synthesis and handling of CAS No. 1012085-50-5 require expertise in organoboron chemistry. Proper storage conditions, such as protection from moisture and oxygen, are essential to maintain its reactivity. Analytical techniques like NMR spectroscopy and HPLC are commonly employed to verify its purity and structural integrity. As the demand for boron-based intermediates grows, suppliers and manufacturers are investing in scalable production methods to meet the needs of academia and industry.

Looking ahead, the compound’s potential extends to emerging fields such as agrochemicals and catalysis. Its modular design allows for the creation of customized derivatives tailored to specific applications. For instance, its incorporation into metal-organic frameworks (MOFs) could unlock new possibilities in gas storage and separation technologies. Furthermore, its role in photoredox catalysis is being explored, offering innovative solutions for light-driven chemical transformations.

In summary, 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine (CAS No. 1012085-50-5) stands at the intersection of chemistry, materials science, and biotechnology. Its multifaceted applications, coupled with its alignment with sustainable practices, position it as a compound of enduring relevance. As research continues to uncover its full potential, this boronic ester derivative is poised to play a pivotal role in shaping the future of functional materials and therapeutic agents.

1012085-50-5 (3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:1012085-50-5)3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine
A897214
Purity:99%/99%
Quantity:250mg/1g
Price ($):154.0/414.0
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