• 1. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

Comprehensive Overview of 2-Chloro-N-(4-sulfamoylphenyl)methylacetamide (CAS No. 101167-02-6)

2-Chloro-N-(4-sulfamoylphenyl)methylacetamide, identified by its CAS number 101167-02-6, is a specialized organic compound with significant applications in pharmaceutical and agrochemical research. This compound features a unique molecular structure combining a chloroacetamide moiety with a sulfamoylphenyl group, making it a versatile intermediate for synthesizing bioactive molecules. Researchers and industry professionals frequently search for 2-Chloro-N-(4-sulfamoylphenyl)methylacetamide synthesis, CAS 101167-02-6 suppliers, and its mechanism of action, reflecting its growing relevance in drug discovery and crop protection.

The compound’s sulfonamide functional group is particularly noteworthy, as it is a common pharmacophore in antibiotics, diuretics, and antidiabetic drugs. Recent studies highlight its potential in targeting carbonic anhydrase enzymes, a hot topic in cancer therapy and glaucoma treatment. Users often inquire about 2-Chloro-N-(4-sulfamoylphenyl)methylacetamide solubility and stability under various pH conditions, which are critical for formulation development. Its chloroacetyl segment also enables covalent bonding with biological targets, a property exploited in proteomics and bioconjugation techniques.

From an industrial perspective, CAS 101167-02-6 is valued for its role in creating herbicide intermediates, aligning with the global demand for sustainable agriculture solutions. Searches for eco-friendly sulfonamide derivatives and green chemistry applications often lead to this compound. Analytical methods like HPLC purity testing and NMR characterization are frequently discussed in technical forums, underscoring the need for precise quality control in its production.

Innovations in crystal engineering have further amplified interest in this compound, as its solid-state properties influence bioavailability and shelf-life. Questions about polymorphism in 2-Chloro-N-(4-sulfamoylphenyl)methylacetamide or compatibility with excipients are common among formulation scientists. Additionally, regulatory compliance queries, such as REACH registration status and patent landscape, dominate professional discussions, reflecting its commercial importance.

In summary, 2-Chloro-N-(4-sulfamoylphenyl)methylacetamide (101167-02-6) bridges multiple scientific disciplines, from medicinal chemistry to materials science. Its dual functionality as a sulfonamide and chloroacetamide derivative positions it as a keystone in developing next-generation therapeutics and agrochemicals, while ongoing research continues to uncover novel applications.

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