• 1. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 2. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives 3-alkylindoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles 3-alkylindoles

Recent Advances in the Study of 4-fluoro-3-methyl-1H-Indole (CAS: 1011484-22-2) in Chemical Biology and Pharmaceutical Research

The compound 4-fluoro-3-methyl-1H-Indole (CAS: 1011484-22-2) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its unique structural properties and potential therapeutic applications. This research brief aims to provide an overview of the latest findings related to this compound, focusing on its synthesis, biological activity, and relevance in drug discovery.

Recent studies have highlighted the role of 4-fluoro-3-methyl-1H-Indole as a versatile scaffold in medicinal chemistry. Its indole core, coupled with the fluorine and methyl substituents, offers a promising platform for the development of novel bioactive molecules. Researchers have explored its utility in the synthesis of kinase inhibitors, antimicrobial agents, and anti-inflammatory compounds, demonstrating its broad applicability in addressing unmet medical needs.

One of the key advancements in the study of 4-fluoro-3-methyl-1H-Indole involves its application in targeted cancer therapies. A 2023 study published in the Journal of Medicinal Chemistry reported the successful incorporation of this compound into a series of small-molecule inhibitors targeting specific oncogenic kinases. The study revealed that the fluorine atom at the 4-position significantly enhances the binding affinity and selectivity of these inhibitors, leading to improved therapeutic efficacy and reduced off-target effects.

In addition to its role in oncology, 4-fluoro-3-methyl-1H-Indole has shown promise in the development of antimicrobial agents. A recent publication in Bioorganic & Medicinal Chemistry Letters detailed the synthesis and evaluation of a series of indole derivatives, including 4-fluoro-3-methyl-1H-Indole, against multidrug-resistant bacterial strains. The results indicated that the fluorinated indole derivatives exhibited potent antibacterial activity, particularly against Gram-positive pathogens, suggesting their potential as lead compounds for new antibiotics.

The synthetic pathways for 4-fluoro-3-methyl-1H-Indole have also been a focus of recent research. A 2022 study in Organic Letters described an efficient, scalable method for its synthesis, utilizing a palladium-catalyzed cross-coupling reaction. This method offers advantages in terms of yield, purity, and environmental sustainability, making it suitable for large-scale pharmaceutical production.

Looking ahead, the potential applications of 4-fluoro-3-methyl-1H-Indole extend beyond its current uses. Ongoing research is exploring its incorporation into novel drug delivery systems, such as nanoparticle-based formulations, to enhance bioavailability and target specificity. Furthermore, computational studies are being conducted to predict its interactions with various biological targets, paving the way for rational drug design.

In conclusion, 4-fluoro-3-methyl-1H-Indole (CAS: 1011484-22-2) represents a valuable building block in modern drug discovery. Its unique chemical properties, coupled with recent advancements in synthesis and application, position it as a key player in the development of next-generation therapeutics. Continued research in this area is expected to yield further insights and innovations, contributing to the advancement of chemical biology and pharmaceutical sciences.

• 392-13-2(5-Fluoro-3-methylindole)
• 1082041-52-8(5-Fluoro-7-methyl-1H-indole)
• 313337-32-5(4-Fluoro-7-methylindole)
• 69467-92-1(6H-Pyrido[4,3-b]carbazole,9-fluoro-5,11-dimethyl-)
• 1041143-61-6(7-fluoro-2,4-dimethyl-9H-Carbazole)
• 1260759-82-7(4-Fluoro-1H-indole-3-carbonitrile)
• 1011484-23-3(6-fluoro-3-methyl-1H-Indole)
• 885522-13-4(4-Fluoro-6-methyl indole)
• 144147-04-6(Quinoline,5-fluoro-4-methyl-)
• 1158310-32-7((4-FLUORO-1H-INDOL-3-YL)METHANOL)