• 1. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 4. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 5. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526

• Catalysts and Inorganic Chemicals Inorganic Compounds Mixed metal/non-metal compounds Transition metal oxoanionic compounds Transition metal sulfates
• Catalysts and Inorganic Chemicals Inorganic Compounds Salt

Recent Advances in the Application of Manganese(II) Sulfate Tetrahydrate (CAS: 10101-68-5) in Chemical Biology and Pharmaceutical Research

Manganese(II) sulfate tetrahydrate (CAS: 10101-68-5) is a versatile inorganic compound widely used in chemical biology and pharmaceutical research. Recent studies have highlighted its critical role in enzymatic reactions, drug synthesis, and as a trace element supplement. This research brief synthesizes the latest findings on the applications and mechanisms of manganese(II) sulfate tetrahydrate, providing insights into its potential in therapeutic development and industrial processes.

One of the most significant advancements involves the use of manganese(II) sulfate tetrahydrate as a cofactor in metalloenzymes. Researchers have demonstrated its essential role in the catalytic activity of manganese-dependent superoxide dismutase (MnSOD), which plays a pivotal role in mitigating oxidative stress in biological systems. A 2023 study published in the Journal of Biological Chemistry revealed that manganese(II) sulfate tetrahydrate enhances the stability and activity of MnSOD, offering potential therapeutic avenues for diseases linked to oxidative damage, such as neurodegenerative disorders and cancer.

In pharmaceutical synthesis, manganese(II) sulfate tetrahydrate has emerged as a cost-effective and efficient catalyst for oxidation reactions. A recent study in Organic Letters (2024) showcased its utility in the synthesis of chiral epoxides, a key intermediate in the production of various drugs. The study reported high enantioselectivity and yield, underscoring the compound's potential to streamline drug manufacturing processes while reducing environmental impact.

Another promising application lies in the field of nutraceuticals. Manganese(II) sulfate tetrahydrate is increasingly recognized as a vital dietary supplement due to its role in bone formation, wound healing, and metabolic regulation. Clinical trials conducted in 2023 highlighted its efficacy in addressing manganese deficiency, particularly in pediatric populations. These findings have spurred interest in developing novel formulations to enhance bioavailability and minimize side effects.

Despite these advancements, challenges remain in optimizing the use of manganese(II) sulfate tetrahydrate. Issues such as dosage control, potential toxicity at high concentrations, and interactions with other metal ions require further investigation. Ongoing research aims to address these gaps, with a focus on nanotechnology-based delivery systems and combinatorial therapies.

In conclusion, manganese(II) sulfate tetrahydrate (CAS: 10101-68-5) continues to be a focal point in chemical biology and pharmaceutical research. Its multifaceted applications—from enzyme catalysis to drug synthesis and supplementation—highlight its enduring relevance. Future studies are expected to explore its integration with emerging technologies, paving the way for innovative therapeutic and industrial solutions.

• 10034-96-5(Manganese sulfate monohydrate)
• 13444-72-9(Sulfuric acid,manganese(3+) salt (3:2))
• 590401-67-5(Sulfate, hexahydrate)
• 7785-87-7(Manganese sulphate)
• 590401-70-0(Sulfate, dodecahydrate)
• 13718-34-8(Sulfuric acid,magnesium potassium salt (2:1:2) (8CI,9CI))
• 13825-74-6(titanium(iv) oxysulfate)
• 13492-24-5(Sulfuric acid, manganese(2+) salt (1:1), heptahydrate)
• 13566-22-8(Sulfuric acid, ammoniummanganese(2+) salt (2:2:1) (8CI,9CI))
• 15244-36-7(Manganese(II) Sulfate Pentahydrate)