• 1. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 2. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 3. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 4. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 5. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615

• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

Recent Advances in the Study of 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile (CAS: 1005206-16-5) in Chemical Biology and Pharmaceutical Research

7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile (CAS: 1005206-16-5) is a heterocyclic compound that has garnered significant attention in recent years due to its potential applications in medicinal chemistry and drug discovery. This compound belongs to the pyrrolopyrimidine family, which is known for its diverse biological activities, including kinase inhibition, anti-inflammatory effects, and anticancer properties. The unique structural features of 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile make it a promising scaffold for the development of novel therapeutic agents.

Recent studies have focused on the synthesis and optimization of 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile derivatives to enhance their pharmacological properties. A study published in the Journal of Medicinal Chemistry (2023) demonstrated that modifications at the 4-carbonitrile position could significantly improve the compound's binding affinity to specific kinase targets, such as JAK2 and EGFR. These findings suggest that 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile derivatives could serve as potent inhibitors for kinase-driven diseases, including certain types of cancer and autoimmune disorders.

In addition to its kinase inhibitory activity, 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile has also been investigated for its potential as an anti-inflammatory agent. A recent preclinical study (Bioorganic & Medicinal Chemistry Letters, 2024) reported that certain derivatives of this compound exhibited strong inhibitory effects on pro-inflammatory cytokines, such as TNF-α and IL-6. These results highlight the compound's potential for treating inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.

Another area of interest is the use of 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile as a building block for the development of fluorescent probes and imaging agents. A study in Chemical Communications (2023) described the synthesis of a fluorescent derivative of this compound, which showed high selectivity for cancer cells in vitro. This innovation opens new avenues for theranostic applications, where the same molecule can be used for both diagnosis and therapy.

Despite these promising developments, challenges remain in the clinical translation of 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile-based therapeutics. Issues such as bioavailability, metabolic stability, and potential off-target effects need to be addressed through further research. Ongoing studies are exploring novel formulation strategies, including nanoparticle-based delivery systems, to overcome these limitations.

In conclusion, 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile (CAS: 1005206-16-5) represents a versatile and promising scaffold in chemical biology and pharmaceutical research. Its diverse biological activities and potential for structural optimization make it a valuable candidate for the development of next-generation therapeutics. Future research should focus on addressing the current challenges and exploring new applications for this compound in precision medicine and theranostics.

• 28732-71-0(Pyrido[2,3-d]pyrimidine,4-methyl-)
• 94169-79-6(2H-Pyrrolo[3,4-c]pyridine-6-carbonitrile, 1,3-dimethyl-)
• 119707-35-6(7H-Pyrrolo[2,3-d]pyrimidine,4,6-dimethyl-)
• 128266-84-2(1H-Pyrrolo[2,3-d]pyrimidine, 2,4-dimethyl- (9CI))
• 205885-19-4(1,8-Naphthyridine-2,7-dicarbonitrile)
• 189882-33-5(1H-pyrrolo[2,3-b]pyridine-6-carbonitrile)
• 945950-37-8(4-Methyl-7H-pyrrolo[2,3-d]pyrimidine)
• 29482-47-1(Pyrido[2,3-d]pyrimidine-4-carbonitrile)
• 26786-73-2(6-Methyl-7H-pyrrolo[2,3-d]pyrimidine)
• 1168106-92-0(5-Bromo-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile)