• 1. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 4. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 5. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines Pyrrolopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines

Comprehensive Overview of 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (CAS No. 1000340-86-2)

6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile, with the CAS number 1000340-86-2, is a heterocyclic organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This compound belongs to the pyrrolopyridine family, a class of nitrogen-containing heterocycles known for their diverse biological activities. The presence of both a methyl group and a carbonitrile moiety in its structure enhances its reactivity and potential applications in drug discovery and material science.

In recent years, the demand for pyrrolopyridine derivatives has surged due to their role as key intermediates in the synthesis of bioactive molecules. Researchers are particularly interested in 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile for its potential as a building block in the development of kinase inhibitors, which are crucial in targeted cancer therapies. The compound's unique structure allows it to interact with various enzymatic targets, making it a valuable candidate for medicinal chemistry applications.

The synthesis of 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile typically involves multi-step reactions, including cyclization and functional group transformations. Advanced techniques such as microwave-assisted synthesis and catalyzed cross-coupling reactions have been employed to improve yield and purity. These methods align with the growing trend toward green chemistry, as researchers seek to minimize waste and reduce the environmental impact of chemical synthesis.

From a commercial perspective, 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile is available through specialized chemical suppliers, often in high purity grades suitable for research and development. Its CAS registry number 1000340-86-2 ensures accurate identification and procurement, which is critical for laboratories and industries requiring consistent quality. The compound's stability under standard storage conditions further enhances its practicality for long-term use.

One of the most frequently asked questions about 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile revolves around its solubility and compatibility with common solvents. Studies indicate that it exhibits moderate solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and methanol, which facilitates its use in various experimental setups. Additionally, its molecular weight and logP value are often discussed in the context of drug-likeness and bioavailability predictions.

The versatility of 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile extends beyond pharmaceuticals. Recent explorations in material science have highlighted its potential as a precursor for organic semiconductors and light-emitting diodes (OLEDs). Its conjugated system and electron-withdrawing carbonitrile group contribute to desirable electronic properties, aligning with the increasing demand for sustainable materials in electronics.

In summary, 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (CAS No. 1000340-86-2) represents a multifaceted compound with broad applications in drug discovery, agrochemicals, and advanced materials. Its structural features and reactivity profile continue to inspire innovative research, addressing some of the most pressing challenges in modern science. As interest in heterocyclic compounds grows, this molecule is poised to remain a focal point in both academic and industrial settings.

• 161468-32-2(3-methyl-4-Isoquinolinecarbonitrile)
• 954112-84-6(2-ethyl-1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile)
• 58309-25-4(1,8-Naphthyridine, 2,3-dimethyl-)
• 10299-69-1(2,3-Dimethyl-1H-pyrrolo2,3-bpyridine)
• 1000340-92-0(5,6-Dimethyl-7-azaindole)
• 267875-39-8(4-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile)
• 954112-82-4(2-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile)
• 1656-95-7(2,6-dimethyl-3,5-Pyridinedicarbonitrile)
• 932039-99-1(Dipyrido[2,3-b:3,2-i]anthyridine-2,9-dicarbonitrile, radical ion(1-))
• 1057077-52-7(Acetonitrile, 2-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-3,4-dihydro-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-)