Clickosomes—using triazole-linked phospholipid connectors to fuse vesicles??

Chemical Communications Pub Date: 2011-11-24 DOI: 10.1039/C2CC16827H

Abstract

Two complementary artificial diether phospholipids were synthesized that can undergo a Cu(I)-catalyzed Huisgen–Sharpless click reaction. The resulting lipid can bridge the membranes of large unilamellar vesicles and cause their aggregation and ultimately their fusion.

Graphical abstract: Clickosomes—using triazole-linked phospholipid connectors to fuse vesicles
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