Bicyclic lactones and racemic mixtures of dimeric styrylpyrones from the leaves of Miliusa velutina?
RSC Advances Pub Date: 2017-05-11 DOI: 10.1039/C7RA01609C
Abstract
A unique class of eight bicyclic lactones with a C18 carbon architecture, named velutinones A–H (1–8), three new dimeric styrylpyrones, velutinindimers A–C (9–11), five known compounds, the kawapyrone, yangonin (12), three flavonoids (13–15), and an acetogenin, cananginone H (16) were isolated from the leaves of Miliusa velutina. The absolute configurations of 2 and 5 were assigned by Mosher's method, whereas ECD, optical rotations, and X-ray crystallographic analysis indicated the racemic nature of compounds 10 and 11. Compounds 2–4 and 7–11 showed antimalarial activity with IC50 values in the range of 5.4–10.0 μM. Moreover, 1–4 and 6–8 displayed cytotoxicity against the KB, MCF7, and NCI-H187 cancer cell lines and Vero cell lines with IC50 values in the range of 4.0–24.1 μM.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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