Bicyclic guanidinium-catalyzed enantioselective phase-transfer alkylation: direct access to pyrroloindolines and furoindolines?
Chemical Communications Pub Date: 2013-08-30 DOI: 10.1039/C3CC46111D
Abstract
Highly enantioselective phase-transfer alkylation of 3-substituted-2-oxindoles with activated bromomethanes is disclosed with a broad substrate scope by using bicyclic guanidinium as a catalyst and a Lewis acid as the co-catalyst. The alkylation adducts are versatile intermediates to accomplish the syntheses of pyrroloindolines and furoindolines.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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