Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications
Organic Chemistry Frontiers Pub Date: 2020-11-09 DOI: 10.1039/D0QO01157F
Abstract
The discovery of the 3-hydroxy-2-aryl acrylate was a significant breakthrough in the field of organic and medicinal chemistry. Due to the presence of both electrophilic and nucleophilic centers, this scaffold acts as a fascinating building block of many bioactive compounds. More importantly, 3-hydroxy-2-aryl acrylate is a vital precursor in the synthesis of natural products and in the development of essential drugs. In this first review, we outline different approaches for preparing 3-hydroxy-2-aryl acrylate with mechanisms and its application in a variety of chemical fields.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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