Baylis–Hillman acetates in organic synthesis: convenient one-pot synthesis of α-carboline framework – a concise synthesis of neocryptolepine?

Organic & Biomolecular Chemistry Pub Date: 2012-09-18 DOI: 10.1039/C2OB26339D

Abstract

A convenient, facile, and one-pot methodology for the synthesis of α-carbolines from Baylis–Hillman (BH) acetates, involving three steps (reactions), (1) mono alkylation of 2-nitroarylacetonitriles with BH-acetates, (2) reduction of nitro group into amino group using Fe/AcOH and (3) formation of two (five and six membered) rings, is presented. This methodology is successfully applied to the synthesis of bioactive alkaloid neocryptolepine.

Graphical abstract: Baylis–Hillman acetates in organic synthesis: convenient one-pot synthesis of α-carboline framework – a concise synthesis of neocryptolepine
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