Br?nsted acid ionic liquid-catalyzed reductive Friedel–Crafts alkylation of indoles and cyclic ketones without using an external reductant?
Green Chemistry Pub Date: 2014-11-13 DOI: 10.1039/C4GC01299B
Abstract
In the absence of an external reductant, C3-cycloalkylated indole could be synthesized through reductive alkylation of indole with cyclic ketone using a sulfonyl-functionalized Br?nsted acid ionic liquid as a catalyst. Water generated in the initial stage of the reaction played a key role in rendering the reductive coupling possible. The reaction proceeds most likely in a radical way.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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