CO2-tuned highly selective reduction of formamides to the corresponding methylamines?
Green Chemistry Pub Date: 2021-09-03 DOI: 10.1039/D1GC02815D
Abstract
We herein describe an efficient, CO2-tuned and highly selective C–O bond cleavage of N-methylated formanilides. With easy-to-handle and commercially available NaBH4 as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO2 has been investigated in detail, and the mechanism is proposed on the basis of experiments.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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