A concise/catalytic approach for the construction of the C14–C28 fragment of eribulin?
Organic & Biomolecular Chemistry Pub Date: 2021-04-26 DOI: 10.1039/D1OB00661D
Abstract
A simple approach for the synthesis of the C14–C28 fragment of eribulin has been developed by employing a one-pot gold-catalyzed alkynol cyclization/Kishi reduction to construct the 1,5-cis-tetrahydropyran unit and a cross-metathesis/Sharpless asymmetric dihydroxylation–cycloetherification to install the 1,4-trans-tetrahydrofuran ring. Use of easily accessible building blocks, ease of operation and catalytic transformations as key reactions for the construction of THF/THP units highlight the current approach.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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