Click and release: fluoride cleavable linker for mild bioorthogonal separation?

Chemical Communications Pub Date: 2015-11-16 DOI: 10.1039/C5CC07692G

Abstract

Herein, we present a water dispersable, magnetic nanoparticle supported “click and release” system. The cleavable linker has been synthesized by using a strain-promoted copper-free “click” reagent to establish the specific link and a fluoride cleavable silane moiety for mild cleavage. Small organic molecules, azide-bearing dyes and functionalized enzymes have been bound to the magnetic particle and released in a bioorthogonal way.

Graphical abstract: Click and release: fluoride cleavable linker for mild bioorthogonal separation
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