Cationic poly(ester amide) dendrimers: alluring materials for biomedical applications?
Journal of Materials Chemistry B Pub Date: 2018-05-15 DOI: 10.1039/C8TB00639C
Abstract
Novel cationic poly(ester amide) dendrimers have been synthesized by copper(I) azide–alkyne cycloaddition (CuAAC) of a tripropargylamine core and azide-terminated dendrons, in turn prepared by iterative amide coupling of the new monomer 2,2′-bis(glycyloxymethyl)propionic acid (bis-GMPA). The alternation of ester and amide groups provided a dendritic scaffold that was totally biocompatible and degradable in aqueous media at physiological and acidic pH. The tripodal dendrimers naturally formed rounded aggregates with a drug that exhibited low water solubility, camptothecin, thus improving its cell viability and anti-Hepatitis C virus (anti-HCV) activity. The presence of numerous peripheral cationic groups enabled these dendrimers to form dendriplexes with both pDNA and siRNA and they showed effective in vitro siRNA transfection in tumoral and non-tumoral cell lines.
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Journal Name：Journal of Materials Chemistry B
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CAS no.: 89640-58-4
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