A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions?

Organic & Biomolecular Chemistry Pub Date: 2012-03-05 DOI: 10.1039/C2OB07074J

Abstract

A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.

Graphical abstract: A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions
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