Catalytic asymmetric cross-dehydrogenative coupling: activation of C–H bonds by a cooperative bimetallic catalyst system?

Chemical Communications Pub Date: 2013-03-20 DOI: 10.1039/C3CC41315B

Abstract

A cooperative bimetallic catalyst system was applied in the catalytic asymmetric cross-dehydrogenative coupling of β-ketoesters and xanthene. Various optically active xanthene derivatives bearing a quaternary stereogenic carbon center were obtained in moderate to good yields (up to 90%) with excellent enantioselectivities (up to 99% ee). Meanwhile, a transition-state model was proposed to explain the origin of the asymmetric induction.

Graphical abstract: Catalytic asymmetric cross-dehydrogenative coupling: activation of C–H bonds by a cooperative bimetallic catalyst system
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