Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane? 365mfc, an environmentally benign alternative solvent?

Green Chemistry Pub Date: 2010-11-19 DOI: 10.1039/C0GC00619J

Abstract

Solkane? 365mfc is a proven environmentally benign alternative solvent for catalyst-free Friedel–Crafts (F–C) alkylations of indoles with trifluoropyruvate and glyoxylate. Their enantioselective variants are also achieved by virtue of the high-affinity of fluorous cinchona alkaloids catalysts to Solkane? 365mfc to provide F–C adducts in excellent yields with good to excellent ees (up to 96% ee).

Graphical abstract: Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane? 365mfc, an environmentally benign alternative solvent
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