A copper-mediated cross-coupling approach for the synthesis of 3-heteroaryl quinolone and related analogues?
Organic & Biomolecular Chemistry Pub Date: 2014-06-11 DOI: 10.1039/C4OB00939H
Abstract
An efficient and practical method for the direct cross-coupling between quinolones and a range of azoles was developed via copper-mediated C–H functionalization. This synthetic strategy provides a convenient access to a variety of C3-heteroaryl quinolones, quinolinone, nalidixic acid, uracil, pyridone and chromone derivatives, which are prominent structural motifs in many biologically active compounds.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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