Chemodosimeter approach for nanomolar detection of Cu2+ ions and their bio-imaging in PC3 cell lines?
RSC Advances Pub Date: 2014-09-01 DOI: 10.1039/C4RA08894H
Abstract
A new rhodamine–azaindole based receptor 4 has been synthesized which selectively senses Cu2+ ions via a fluorescence resonance energy transfer (FRET) process in acetonitrile while in mixed aqueous media it undergoes Cu2+ promoted hydrolysis among the various metal ions tested (Pb2+, Ba2+, Fe3+, Cd2+, Ag+, Zn2+, Hg2+, Cu2+, Ni2+, Co2+, Fe2+ and Mg2+). The time resolved fluorescence studies also support the Cu2+ promoted hydrolysis of receptor 4 in mixed aqueous media. The detection limit for Cu2+ ions has been found to be 20 nM. The potential biological application of probe 4 is evaluated for in vitro detection of copper ions in prostate cancer (PC3) cell lines.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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