Carbon–carbon bond activation by B(OMe)3/B2pin2-mediated fragmentation borylation?
Chemical Science Pub Date: 2021-11-02 DOI: 10.1039/D1SC04487G
Abstract
Selective carbon–carbon bond activation is important in chemical industry and fundamental organic synthesis, but remains challenging. In this study, non-polar unstrained Csp2–Csp3 and Csp2–Csp2 bond activation was achieved by B(OMe)3/B2pin2-mediated fragmentation borylation. Various indole derivatives underwent C2-regioselective C–C bond activation to afford two C–B bonds under transition-metal-free conditions. Preliminary mechanistic investigations suggested that C–B bond formation and C–C bond cleavage probably occurred in a concerted process. This new reaction mode will stimulate the development of reactions based on inert C–C bond activation.
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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