Catalytic asymmetric synthesis of tetrahydrocarbazoles

Chemical Communications Pub Date: 2019-05-08 DOI: 10.1039/C9CC02486G

Abstract

Chiral tetrahydrocarbazoles (THCs) are prevalent in numerous natural indole alkaloids as well as synthetic pharmaceuticals, and exhibit a broad spectrum of bioactivities. As such, the development of efficient synthetic methodologies for the synthesis of chiral THCs is of substantial interest. The advent of asymmetric catalysis provides a powerful platform to assemble chiral THC motifs and great efforts have been devoted to this field over the past decades. In this feature article, we summarise recent advances in catalytic asymmetric synthesis of THCs, with particular emphases on reaction types and reaction mechanism.

Graphical abstract: Catalytic asymmetric synthesis of tetrahydrocarbazoles
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