Cascade imination, Buchwald–Hartwig cross coupling and cycloaddition reaction: synthesis of pyrido[2,3-d]pyrimidines?
RSC Advances Pub Date: 2015-02-25 DOI: 10.1039/C5RA00725A
Abstract
A novel and efficient palladium catalyzed method was developed for the synthesis of wide range of pyrido[2,3-d]pyrimidines, using readily available β-bromovinyl/aryl aldehydes and 6-amino-1,3-dialkyluracils as the starting materials with good yields. This reaction proceeds via cascade imination/Buchwald–Hartwig cross coupling/cycloaddition reactions under microwave irradiation and solvent free conditions.
![Graphical abstract: Cascade imination, Buchwald–Hartwig cross coupling and cycloaddition reaction: synthesis of pyrido[2,3-d]pyrimidines](http://scimg.chem960.com/usr/1/C5RA00725A.jpg)
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Journal Name：RSC Advances
research_products
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CAS no.: 89640-58-4
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