Carbon–carbon bond cleavage by cytochrome P450BioI (CYP107H1)?

Chemical Communications Pub Date: 2003-11-17 DOI: 10.1039/B311652B

Abstract

Cytochrome P450BioI (CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional P450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported.

Graphical abstract: Carbon–carbon bond cleavage by cytochrome P450BioI (CYP107H1)
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