B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines?
Organic & Biomolecular Chemistry Pub Date: 2021-04-13 DOI: 10.1039/D1OB00316J
Abstract
A highly efficient B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines in the presence of water and pinacolborane was developed. Regioselective β-deuteration of tertiary amines was achieved with high chemo- and regioselectivity. D2O was used as a readily available and cheap source of deuterium. Mechanistic studies indicated that B(C6F5)3 could activate water to promote the protonation and reduction of enamines.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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