“On water” nano-Cu2O-catalyzed CO-free one-pot multicomponent cascade cyanation–annulation–aminolysis reaction toward phthalimides?
Organic & Biomolecular Chemistry Pub Date: 2021-02-01 DOI: 10.1039/D1OB00073J
Abstract
An efficient nano-Cu2O-catalyzed cascade multicomponent reaction of 2-halobenzoic acids and trimethylsilyl cyanide with diverse amines was developed using water as a solvent, affording versatile N-substituted phthalimide derivatives in moderate to excellent yields. This novel strategy features carbon monoxide gas-free, environmentally benign, one-pot multistep transformation, commercially available reagents, a cheap catalyst without any additives, wide functional group tolerance, and operational convenience.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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