Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides?
Chemical Communications Pub Date: 2016-02-26 DOI: 10.1039/C6CC00890A
Abstract
DNA-intercalating polyketide glycosides are important leads for cancer therapeutics, yet their use is often limited by their low solubility and challenging synthetic protocols. To overcome these limitations, we employed 1,4′-bipiperidine-1′-carbamate residues as sugar surrogates in daunorubicin and chartreusin, yielding water-soluble derivatives and prodrugs with dramatically improved antiproliferative activities.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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