Asymmetric syntheses of spiro[benzofuro-cyclopenta[1,2-b]indole–indoline] scaffolds via consecutive cyclization?
Chemical Communications Pub Date: 2021-01-26 DOI: 10.1039/D0CC08083G
Abstract
An efficient method to construct enantioenriched spiro[benzofuro-cyclopenta[1,2-b]indole–indoline] scaffolds via consecutive cyclization is described here. The new scaffolds possess five successive chiral stereogenic centers and two spiroheterocycles. A range of highly enantioenriched scaffolds has been obtained with up to 93% yield, 99% ee and >19?:?1 d.r. catalyzed by Br?nsted acid catalysts.
![Graphical abstract: Asymmetric syntheses of spiro[benzofuro-cyclopenta[1,2-b]indole–indoline] scaffolds via consecutive cyclization](http://scimg.chem960.com/usr/1/D0CC08083G.jpg)
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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