Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones?
RSC Advances Pub Date: 2019-12-20 DOI: 10.1039/C9RA09478D
Abstract
A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF3.Et2O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed. The reaction proceeds under solvent-free conditions, tolerates a wide range of functional groups, and provides rapid access to a range of acridones in good to excellent yields. Several of the synthesized acridones exhibited potent antimalarial activities against CQ sensitive and multi-drug resistant (MDR) parasites.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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