Catalytic asymmetric conjugate addition of Grignard reagents to chromones?

Chemical Communications Pub Date: 2013-05-16 DOI: 10.1039/C3CC43105C

Abstract

A highly regio- and enantioselective copper catalysed direct conjugate addition of Grignard reagents to chromones has been developed taking advantage of the reduced reactivity of the resulting magnesium enolates. This methodology tolerates a broad scope of alkyl Grignards including secondary alkyl magnesium reagents as well as functionalised chromones.

Graphical abstract: Catalytic asymmetric conjugate addition of Grignard reagents to chromones
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