Catalytic activity of halohydrin dehalogenases towards spiroepoxides?
Organic & Biomolecular Chemistry Pub Date: 2012-04-25 DOI: 10.1039/C2OB25470K
Abstract
A novel activity of halohydrin dehalogenases towards spiroepoxides has been found. The enzyme from Arthrobacter sp. (HheA) catalysed highly regioselective azidolysis of spiroepoxides containing 5, 6 and 7-membered cycloalkane rings, while the enzyme from Agrobacterium radiobacter (HheC), besides high regioselectivity, also displayed moderate to high enantioselectivity (E up to >200) that can be applied for the kinetic resolution of chiral spiroepoxides. The orientations of spiroepoxides in the active site of halohydrin dehalogenases were studied by quantum-chemical calculations and docking simulations. Analyses of the complexes obtained revealed the origins of diastereoselectivity and enantioselectivity of the investigated biotransformations.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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