Bioluminescent probe for detecting endogenous hypochlorite in living mice?
Organic & Biomolecular Chemistry Pub Date: 2017-12-19 DOI: 10.1039/C7OB02842C
Abstract
As a kind of biologically important reactive oxygen species (ROS), hypochlorite (ClO?) plays a crucial role in many physiological processes. As such, endogenous ClO? is a powerful antibacterial agent during pathogen invasion. Nonetheless, excessive endogenous ClO? could pose a health threat to mammalian animals including humans. However, the detection of endogenous ClO? by bioluminescence probes in vivo remains a considerable challenge. Herein, based on a caged strategy, we developed a turn-on bioluminescent probe 1 for the highly selective detection of ClO?in vitro and imaging endogenous ClO? in a mouse inflammation model. We anticipate that such a probe could help us understand the role of endogenous ClO? in a variety of physiological and pathological processes.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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