Catalytic asymmetric Meerwein–Ponndorf–Verley reduction of glyoxylates induced by a chiral N,N′-dioxide/Y(OTf)3 complex?

Chemical Communications Pub Date: 2017-02-23 DOI: 10.1039/C7CC00273D

Abstract

An asymmetric Meerwein–Ponndorf–Verley (MPV) reduction of glyoxylates was for the first time accomplished via an N,N′-dioxide/Y(OTf)3 complex with aluminium alkoxide and molecular sieves (MSs) as crucial additives. A variety of optically active α-hydroxyesters were obtained with excellent results. A possible reaction mechanism was proposed based on the experiments.

Graphical abstract: Catalytic asymmetric Meerwein–Ponndorf–Verley reduction of glyoxylates induced by a chiral N,N′-dioxide/Y(OTf)3 complex
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