Carbonates: eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics?

Green Chemistry Pub Date: 2010-10-11 DOI: 10.1039/C0GC00229A

Abstract

The palladium-catalysed direct 2-, 4- or 5-arylation of a wide range of heteroaromatics with aryl halides proceed in moderate to good yields using the eco-friendly solvents carbonates. The best yields were obtained using benzoxazole or thiazole derivatives. The arylation of furan, thiophene, pyrrole, imidazole or isoxazole derivatives was found to require a more elevated reaction temperature.

Graphical abstract: Carbonates: eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics
Recommended Literature