Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation?
Chemical Communications Pub Date: 2020-08-19 DOI: 10.1039/D0CC05031H
Abstract
A general procedure for the late-stage [11C], [13C] and [14C]carbon isotope labeling of cyclic carbamates is reported. This protocol allows the incorporation of carbon dioxide, the primary source of carbon-14 and carbon-11 radioisotopes, in a direct, cost-effective and sustainable manner. A disconnection/reconnection strategy, involving ring opening/isotopic closure, was also implemented.
![Graphical abstract: Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation](http://scimg.chem960.com/usr/1/D0CC05031H.jpg)
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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