Assessment and use of two silicon carbide multi-well plates for library synthesis and proteolytic digests using microwave heating

Organic & Biomolecular Chemistry Pub Date: 2009-04-21 DOI: 10.1039/B902112D

Abstract

The use of two silicon carbide plates is reported for the preparation of three libraries of organic molecules using microwave heating. In addition, a preliminary study has been carried out, showing that one of the plates can also be used in a proteomics setting. Both the 24-position and 48-position plates heated evenly when irradiated with microwave energy. The 48-position plate was used to prepare a library of N-aryl functionalized β-amino esters via an aza-Michael reaction between anilines and Michael acceptors. The 24-position plate was used to prepare a library of biaryls via a Suzuki coupling methodology and a library of 1,4-dihydropyridines via a Hantzsch synthesis. The 48-position plate was also used to perform the proteolytic digestion of insulin chain B by trypsin.

Graphical abstract: Assessment and use of two silicon carbide multi-well plates for library synthesis and proteolytic digests using microwave heating
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