Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics?

Chemical Communications Pub Date: 2012-07-26 DOI: 10.1039/C2CC34791A

Abstract

We describe the design and synthesis of a non-peptidic β-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.

Graphical abstract: Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics
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