Bis(oxazoline)-copper catalyzed enantioselective hydrophosphonylation of aldehydes?

RSC Advances Pub Date: 2014-06-30 DOI: 10.1039/C4RA03269A

Abstract

A highly enantioselective copper-catalyzed hydrophosphonylation of aldehydes in the presence of bis(oxazoline) ligand is presented. The reaction proceeded smoothly under mild conditions. The resulting α-hydroxyphosphonates were obtained with high yields as well as enantioselectivities (up to 98% ee).

Graphical abstract: Bis(oxazoline)-copper catalyzed enantioselective hydrophosphonylation of aldehydes
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