Asymmetric total synthesis of pleurospiroketals A and B?
Chemical Communications Pub Date: 2018-08-20 DOI: 10.1039/C8CC06185H
Abstract
The first asymmetric total synthesis of pleurospiroketals A and B has been accomplished in 16 steps from 5-methyl-5-hexenoic acid. Key features of the synthesis are the highly syn-selective Evans aldol reaction, ring-closing metathesis, highly diastereoselective dihydroxylation and acid-mediated spiroketalization.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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